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Journal Publications

Fischer Lab Publications

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  • The Synthesis of Nucleoside 2′, 3′‐Cyclic Monophosphate Analogs with Regio‐and Stereospecificity. M Nassir, A Saady, NP Cohen, B Fischer Current Protocols, 2022, 1 (11), e287

  • Hydrolytic (in) stability of phosphate isosteres. M Nassir, A Isaak, B Fischer. European Journal of Medicinal Chemistry, 2022, 244, 114836

  • Addressing regio- and stereo-specificity challenges in the synthesis of nucleoside 2′,3′-cyclic monophosphate analogs – a rapid and facile synthesis of nucleoside-2′,3′-O,O-phosphoro-thioate or -selenoate, and elucidation of the origin of the rare specificity. M. Nassir, L. Balaom, and B. Fischer. Chemical Communications, 2020, 56, 11633 – 11636.

  • Specific, sensitive, and quantitative detection of HER-2 mRNA breast cancer marker by fluorescent light-up hybridization probes. A. Saady, Melissa Wojtyniak, Eli Varon, Verena Boettner, Noa Kinor, Yaron Shav-Tal, Christian Ducho and Bilha Fischer. Bioconjugate Chemistry. 2020, 1-31.

  • Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells. A.Saady, E. Varon, A. Jacob, Y. Shav-Tal, and B. Fischer. Dyes Pigments. 2020, 174, 107986-107998.

  • β-Cyanuryl-ribose, β-Barbituryl-ribose, and 6-Azauridine as Uridine Mimetics. H. Salameh, M. Afri, H. Gottlieb, and B. Fischer. ACS Omega, DOI: 10.1021/acsomega.0c04788, 2020.

  • Synthesis of 2'-Deoxyuridine Modified with a 3,5-Difluoro-4-Methoxybenzylidene Imidazolinone Derivative for Incorporation into Oligonucleotide Probes for Detection of HER2 Breast Cancer Marker. A. Saady, N.Y. Steinman, M. Wojtyniak , C. Ducho and B. Fischer. Curr Protoc Nucleic Acid Chem. 2020, 80, (1), e104.

  • An oligonucleotide probe incorporating the chromophore of green fluorescent protein is useful for the detection of HER-2 mRNA breast cancer marker.A. Saady, Verena Bottner, Melissa Meng, Eli Varon, Yaron Shav-Tal, Christian Ducho and Bilha Fischer. Eur. J. Med. Chem. 2019, 173, 99-106.

  • Synthesis and Photophysical Properties of Conjugates of Green Fluorescent Protein (GFP) Chromophore and 2’-deoxy-Uridine as Potential Probes Developed as Labelled Building Blocks for Oligonucleotide Probes  A. Saady and B. Fischer. Journal of Pharmacy and Pharmacology. 2019, 7, 510-519

  • Adenine-(methoxy)​ethoxy-Pα,α-dithio–triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes. M. Nassir, S. Mirza, U. Arad, S. Lee, M. Rafehi, I. Y. Attah, C. Renn, H. Zimmermann, J. Pelletier, J. Sévigny, C. E. Müller, and B. Fischer. Org. Biomol. Chem. 2019, 17, 9913-9923.

  • Structure-Activity Relationship Study of NPP1 Inhibitors Based on Uracil-N1-(methoxy)ethyl-β-phosphate Scaffold. Molhm Nassir, Julie Pelletier, Uri Arad, Guillaume Arguin, Fernand-Pierre endron,dJean Sévigny and Bilha Fischer.E. J. Med. Chem. 2019, 184, 111754.​

  • Aminomethylene-Phosphonate Analogue as a Cu(II) Chelator: Characterization and Application as an Inhibitor of Oxidation Induced by Cu(II)-Prion Peptide Complex.   Natalie Pariente Cohen, E. Lo Presti, S. Dell’Acqua, T. Jantz, L. J. W. Shimon, B. Levi Hevroni,  N. Levy, L. Elbaz, L. Casella, and B. Fischer. Inorg. Chem. 2019, 58 (14), 8995-9003.​

  • Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuating undesired NPPase activity in human osteoarthritic chondrocytes. Molhm Nassir, Uri Arad, Sang-Yong Lee, Shani Journo, Salahuddin Mirza, Christian Renn, Christa E. Müller and Bilha Fischer. Purinergic signalling. 2019, 15(2), 247-26​​

  • Highly Selective and Potent NPP1 Inhibitors Based on Uridine-5’-Phosphorodithioate Analogues. Vadim Zelikman, Julie Peltier, Aviad Sela, Jean Sevigny, and Bilha Fischer. J. Med. Chem. 2018, 61, 3939-3951

  • An eNPP1-specific inhibitor attenuates extracellular ecto-pyrophosphatase activity in human osteoarthritic cartilage: implications for the development of a CPPD disease modifying drug. Ortal Shimon, Shuli Sabetsky, Sarah Kenigsberg, Asaf Levin, Shani Journo, Aviram Gold, Michael Drexler, Ori Elkayam, Bilha Fischer and Uri Arad. Rehumatolog. 2018, 57(8), 1472-1480.​

  • A promising multifunctional biocompatible drug candidate for delaying the progression of Alzheimer’s disease. Hadar Segal-Gavish, Ortal Shimon, Daniel Offen, and Bilha Fischer. Journal of Alzheimer's Disease, 58, 389-400, 2017

  • Efficient Zn(II) chelators based on aminomethylene-phosphonate scaffold: Synthesis and characterization. Bosmat Levi Hevroni, Thomas Jantz, and Bilha Fischer. Eur. Inorg. Chem. DOI: 10.1002/ejic.201700210, 2017​

  • Nucleoside-2’,3’/3’,5’-Bis(thio)phosphate Analogues Dissolve Efficiently Amyloid Beta(1-42)–Metal Ion Aggregates. Bosmat Levi Hevroni, and Bilha Fischer. Org. Biomol. Chem. 14, 4640 – 4653, 2016

  • Identification of Highly Promising Anti-Oxidants / Neuroprotectants Based on Nucleoside Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. Sagit Azran, Ortal Danino, Daniel Forster, Sarah Kenigsberg, Georg Reiser and Bilha Fischer. J. Med. Chem. 58, 2015, 8427−8443.

  • Synthesis and Structure-Activity Relationship of Uracil Nucleotide Derivatives as Antagonists of Human P2Y6 Receptor. Diana Meltzer, Ofir Ben Yaacov, Guillaume Arguin, Yael Nadel, Fernand-Pierre Gendron, and Bilha Fischer. Bioorg. Med. Chem. 23, 5764-5773, 2015.

  • Novel Crown-Ether-Methylenediphosphonotetrathioate Hybrids as Zn(II) Chelators. Diana Meltzer, Aviran Amir, Linda J. W. Shimon, and Bilha Fischer. Dalton Trans. 44, 21080-21073, 2015

  • ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Ortal Danino, Shlomo Grossman and Bilha Fischer. BBRC, 460, 446-450, 2015.

  • Adenosine/Guanosine-3',5’-Bis-Phosphate as Biocompatible and Selective Zn2+-Ion Chelators. Characterization and Comparison with Adenosine/Guanosine-5’-Di-Phosphate. A. H. Sayer, E. Blum, D. T. Major, A. Vardi-Kilshtain, B. Levi Hevroni, and B. Fischer. Dalton Trans. 44, 7305-7317, 2015.

  • Synthesis and Evaluation of a Novel Photoresponsive Quencher for Fluorescent Hybridization Probes. M. Kovaliov, C. Wachtel, E. Yavin, and B. Fischer. Org. Biomol. Chem. 12, 7844-7859, 2014.

  • Novel Cu(I)-Selective Chelators Based on a Bis(phosphorothioyl)amide Scaffold. Fischer, B.; Amir, A.; Ezra, A. Inorg. Chem. 53(15):7901-8, 2014.

  • Phenyl-Imidazolo-Cytidine Analogues: Structure-Photophysical-Activity Relationship and Potential Use for SNP Typing. M. Kovaliov, M. Weitman, D. T. Major, and B. Fischer. J. Org. Chem. 79(15):7051-62, 2014.

  • 2-Hexylthio-β, γ -CH2-ATP is a specific NTPDase2 inhibitor. I. Gillerman, J. Lecka, L. Simhaev, M. N. Munkonda, M. Fausther, M. Martín-Satué, H. Senderowitz, J. Sévigny, and B. Fischer. J. Med. Chem. 57 (14), 5919–5934, 2014.

  • Highly potent and selective NPP1 inhibitors based on ATP - (α or γ) thio - (α, β or β, γ)-methylene scaffold. Y. Nadel, Y. Gliad, J. Lecka, G. Ben-David, H. Sendrowitz, J. Sévigny, D. Förster, G. Reiser, J. Camden, G. A. Weisman, and B. Fischer. J. Med. Chem. 57, 4677–4691, 2014.

  • Development of fluorescent double-strand probes labeled with 8-(p-CF3-cinnamyl)-adenosine for the detection of cyclin D1 breast cancer marker L. Zilbershtein-Shklanovsky,  P. Kafri, Y. Shav-Tal, E. Yavin, and B. Fischer. E. J. Med. Chem., 79, 77-88, 2014.

  • Detection of Cyclin D1 mRNA by hybridization sensitive NIC - oligonucleotide probe. M. Kovaliov, M. Segal, P. Kafri, E. Yavin, Y. Shav-Tal, and B. Fischer. Bioorg. Med. Chem. 22, 2613-2621, 2014.

  • 5-OMe-uridine-5’-O-(α-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y6 receptor protects against death-receptor mediated glial apoptosis. M. Haas, T. Ginsburg-Shmuel, B. Fischer, G. Reiser, accepted to publication, Neuroscience Letters, 578, 80-4, 2014.

  • Nucleoside 5'-phosphorothioate derivatives are highly effective neuroprotectants. O. Danino, N. Giladi, S. Grossman, and B. Fischer. Biochem. Pharmacol. 88, 384-392, 2014.

  • Nucleoside-2’,3’/3’,5’-Bis(thio)phosphate Analogues are Promising Antioxidants Acting Mainly via Cu+/Fe2+ Ion Chelation. B. Levi Hevroni, A. H. Sayer, E. Blum, and B. Fischer. Inorg. Chem. 53, 1594–1605, 2014.

  • Rules for the design of highly fluorescent probes: 8-(substituted cinnamyl)-adenosine analogues. Lital Zilbershtein, Michal Weitman, Dan-Thomas Major, and Bilha Fischer. J. Org. Chem. 78(23):11999-2008, 2013.

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  • Characterization of Complexes of Nucleoside-5’-Phosphorothioate Analogues with Zinc Ions. A. H. Sayer, Y. Itzhakov, N. Stern, Y. Nadel and B. Fischer. Inorg. Chem., 52, 10886–10896, 2013.

  • Adenosine-5'-α-borano, β,γ-dihalomethylene- tri-phosphate analogues as potent and selective NPP inhibitors. J. Lecka, G. Ben-David, S. Eliahu, J. Pelletier, J. Oscar Jr., P. Luyindula, B. Fischer, H. Senderowitz, and J. Sévigny. J. Med. Chem., 56, 8308-8320, 2013.

  • Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B,β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y11 receptor. Haas M., Ben-Moshe I., Fischer B., Reiser G. Biochem Pharmacol, 86, 645-655, 2013.

  • Highly Efficient Biocompatible Neuroprotectants with Dual-activity as Antioxidants and P2Y-Receptor Agonists. S. Azran, D. Forster, O. Danino, Y. Nadel, G. Reiser and B. Fischer. J Med Chem, 56, 4938-4952, 2013.

  • Selective detection of mRNA of Cyclin D1 breast cancer marker by a novel duplex-DNA probe. M. Segal, E. Yavin, and B. Fischer. . J Med Chem 56, 4860-4869, 2013.

  • Phosphorothioate Nucleotide Derivatives as Oxidative Stress Protectants in PC12 Cells. O. Danino, S. Grossman, and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids, 32, 1–21, 2013.

  • p-Substituted-Phenyl-Imidazolo-Cytidine Analogues as Potential Fluorescent Probes. M. Kovaliov, M. Segal, and B. Fischer. Tetrahedron, 69, 2013, 3698-3705.

  • Methylenediphosphonotetrathioate: Synthesis, Characterization, and Chemical Properties A. Amir, A. H. Sayer, A. Ezra, and B. Fischer. Inorg Chem., 2013, 52, 3133-40.

  • 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. by Lecka, J.; Gillerman, I.; Munkonda, M.; Brosseau, J.-P.; Cadot, C.; Fausther, M.; Martín-Satué, M.; D'Orléans-Juste, P.; Rousseau, E.; Poirier, D.; Künzli, B.; Fischer, B.; Sévigny, J. Br. J. Pharmacol, 2013. 169(1):179-96.

  • A Novel Scaffold: O,O’-Diester-methylenediphosphonotetrathioate- Synthesis, Characterization, and Potential Applications. A. Amir, R. Zagalsky, L. J. W. Shimon and B. Fischer. 2012, J Org Chem, 2013, 78, 270-277.

  • Identification of a Promising Insulin Secretagogue Based on a P2Y1 Receptor Agonist. Yelovitch, S.; Barr, H.; Camden, J.; Weisman, G.; Shai, E.; Varon, D.; Fischer, B. J Med Chem, 2012, 55, 7623−7635.

  • UDP Made a Highly Promising Stable, Potent, and Selective P2Y6-Receptor Agonist upon Introduction of a Boranophosphate Moiety. T. Ginsburg-Shmuel, M. Haas, M. Schumann, G. Reiser, Y. Nadel, and B. Fischer. Bioorg. Med. Chem., 2012, 20, 5483-5495.

  • Nucleoside-5’-phosphorothioate Analogues are Biocompatible Antioxidants Dissolving Efficiently Amyloid Beta –Metal Ion Aggregates. A. Amir, E. Shmuel, R. Zagalsky, A. Sayer, Y. Kogon, and B. Fischer. Dalton Transactions, 2012, 41, 8539 – 8549.

  • Studies of Mg2+/Ca2+ complexes of naturally occurring dinucleotides: potentiometric titrations, NMR, and molecular dynamics N. Stern, D. T. Major, H. E. Gottlieb, D. Weizman, A. H. Sayer, E. Blum and B. Fischer. J. Biol. Inorg. Chem. 2012, 17, 861-879..

  • Minimally Extended Fluorescent Uridine Analogues as Potential Probes for Detection of Genetic Material. Synthesis and Spectral Properties of Uridine Analogues. Meirav Segal and B. Fischer. Org. Biomol. Chem. 2012, 10 (8), 1571 – 1580.

  • Identification of Dinucleoside Poly(borano)phosphate Analogues as Selective and Stable P2Y Receptor Agonists. S. Yelovitch, J. Camden, G. A. Weisman, and B. Fischer. J. Med. Chem., 2012, 55, 437-448.

  • 8-(p-CF3-cinnamyl)-modified purine nucleosides as promising fluorescent probes.  L. Zilbershtein, A. Silberman, and B. Fischer. Org. Biomol. Chem. 2011, 9 (22), 7763 – 7773.

  • Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. I. Gillerman and B. Fischer J. Med. Chem., 2011, 54, 107-121.

  • Diadenosine Poly(borano)phosphate analogues as specific NPP inhibitors. S. Eliahu, J. Lecka, G. Reiser, F. Bigonnesse, J. Sévigny, and B. Fischer. J. Med. Chem., 2010, 53, 8485-8497.

  • What is the conformation of physiologically-active dinucleoside polyphosphates in an aqueous solution? Conformational analysis of free dinucleoside polyphosphates by NMR and molecular dynamics simulations. N. Stern, D. T. Major, H. E. Gottlieb, D. Weizman, B. Fischer. Org. Biomol. Chem. 2010, 8, 4637 - 4652.

  • Neither Ab28 nor a combination of Ab28 and physiological reductants trigger enhanced production of OH radical in cell - free oxidizing systems. R. Baruch-Suchodolsky and B. Fischer. 2010, submitted to publication.

  • An improved one-pot synthesis of nucleoside 5’-triphosphate analogues. I. Gillerman and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids 2010, 29, 245-256.

  • 2-MeS-β,γ-CCl2-ATP is a potent agent for reducing intraocular pressure. S. Eliahu, A. Martín-Gil, M. Perez de Lara, J. Camden, G. A. Weisman, J. Lecka, J. Sévigny and B. Fischer. J. Med. Chem., 2010, 53, 3305–3319.

  • A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. S. Eliahu, H. M. Barr, J. Camden,  G. A. Weisman, and B. Fischer. J. Med. Chem., 2010, 53, 2472–2481.

  • Oligonucleotides as potent antioxidants. E. Zobel, E. Yavin, H. E. Gottlieb, M. Tzion, and B. Fischer, JBIC, 2010, 15, 601-620.

  • 5-OMe-UDP is a potent and selective P2Y6-receptor agonist. T. Ginsburg-Shmuel, M. Haas, M. Schumann, G. Reiser, O. Kalid, N. Stern, and B. Fischer. J. Med. Chem., 2010, 53, 1673–1685.

  • Aβ40, either soluble or aggregated, is a remarkably potent antioxidant in cell – free oxidative systems. R. Baruch-Suchodolsky and B. Fischer. Biochemistry, 2009, 48, 4354-4370.

  • Identification of hydrolytically stable and selective P2Y1-receptor agonists. S. Elyahu, J. Camden, J. Lecka, G. A. Weisman, J. Sévigny, S. Gélinas, and B. Fischer. Eur. J. Med. Chem. 2009, 44, 1525-1536.

  • Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis. D. Ecke, B. Fischer, G. Reiser. Br. J. Pharmacol. 2008, 155, 1250-1255.

  • Cu(I)/Cu(II)/Fe(II)-Complexes of soluble Aβ1-28 are potent antioxidants. R. Baruch-Suchodolsky and B. Fischer. Biochemistry, 2008, 47, 7796-7806.

  • Can nucleotides prevent Cu-induced oxidative damage? R. Baruch-Suchodolsky and B. Fischer. J. Inorg. Biochem. 2008, 102, 862-881.

  • Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. J. Zylberg, D. Ecke, B. Fischer, and G. Reiser. Biochem. J. 2007, 405, 277-286.

  • Molecular recognition of adenosine deaminase. 15N NMR studies. A. Laxer, H. E. Gottlieb, and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, 161-180.

  • Opposite diastereoselective activation of P2Y1 and P2Y11 nucleotide receptors by adenosine 5'-O-(1-boranotriphosphate) analogues. D. Ecke, M. Tulapurkar, V. Nahum, B. Fischer, and G. Reiser. Br. J. Pharmacol. 2006, 149, 416 – 423.

  • Nucleotides and inorganic phosphates as potential antioxidants. Y. Richter, and B. Fischer. J. Biol. Inorg. Chem. 2006, 11, 1063-1074.

  • Fluorescent N2,N3-e-Adenosine: Synthesis and Spectroscopic Properties. E. Sharon, A. Levesque, D. Ecke, J. Sevigny, G. Reiser, and B. Fischer. ChemBioChem, 2006, 7, 1361-1374.

  • Diadenosine- and diuridine-poly(borano)phosphate analogues: Synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2-receptors. V. Nahum, M. Tulapurkar, S. A. Levesque, J. Sevigny, G. Reiser, and B. Fischer. J. Med. Chem. 2006, 49, 1980-1990.

  • Fluorescent ATP analogues for probing physicochemical properties of proteins. Synthesis, biochemical evaluation, and sensitivity to physicochemical properties of the medium. E. Sharon, G. Zündorf, S. A. Levesque, A. R. Beaudoin, G. Reiser, and B. Fischer. Bioorg. Med. Chem. 2004, 12, 6119-6135.

  • Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5’-O-(1-boranotriphosphate) derivatives. Tulapurkar, M. E.; Laubinger, W.; Nahum, V.; Fischer B.; Reiser, G. Br. J. Pharmacol. 2004, 142, 869-878.

  • Molecular recognition in purinergic receptors. Part 2. Stereo- and diastereo-selectivity of the h-P2Y1-receptor. Major, D. T., Nahum, V., Y. Wang, G. Reiser, and B. Fischer. J. Med. Chem. 47, 2004, 4405-4416.

  • Molecular recognition in purinergic receptors. Part 1. A comprehensive computational study of the h-P2Y1-receptor. Major, D. T. and Fischer, B. J. Med. Chem. 47, 2004, 4391-4404.

  • Inorganic boranophosphate: A novel inorganic phosphate mimic. Preparation, Characterization, and Properties. Nahum, V. and Fischer, B. Eur. J. Inorg. Chem. 2004, 4124 - 4131.

  • Theoretical study of the pH-dependent photophysics of N1,N6-ethenoadenine and N3,N4-ethenocytosine. Major, D. T. and Fischer, B. J. Phys. Chem. 2003, 107, 8923 - 8931.

  • Photoaffinity labeling on magnetic microspheres (PALMm) methodology for topographic mapping: preparation of PALMm reagents and demonstration of biochemical relevance. Halbfinger, E.; Gorochesky, K.; Levesque, S. A.; Beaudoin, A. R.; Sheihet, L.; Margel, S.; Fischer, B. Org. Biomol. Chem. 2003, 1, 2821 - 2832. 

  • Characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II). Richter, Y.; Fischer, B. Nucleosides Nucleotides Nucleic Acids 2003, 22, 1757-1780.

  • 5’-O-(1-Boranotriphosphate)-adenosine derivatives as novel P2Y1-receptor agonists. Nahum, V.; Ubl, J.; Reiser, G.; Levesque S.; Beaudoin, A. R.; Fischer B. J. Med. Chem. 2002, 45, 5384-5396.

  • Protonation studies of modified adenine and adenine nucleotides by theoretical calculations and 15N NMR. Major, D. T.; Laxer, A.; Fischer, B. J. Org. Chem. 2002, 67, 790-802.

  • Diethyl chlorophosphite – a versatile reagent. Jie, Z.; Rammoorty, V.; Fischer, B. J. Org. Chem. 2002, 67, 711-719.

  • 2-Thioether-5’-O-(1-thiotriphosphate) adenosine derivatives as new insulin secretagogues acting through P2Y-receptors. II. Pharmacological evaluation and chemical stability of 2-benzylthioether-5’-O-(1-thiotriphosphate)-adenosine. Hillaire-Buys, D.; Shahar, L. M.; Fischer, B.; Chulkin, A.; Linck, N.; Chapal, J.; Loubatieres-Mariani, M. M.; Petit, P. Drug Dev. Res. 2001, 53, 33-43.

  • (15N5)-Labeled adenine derivatives. Synthesis and tautomerism studies by 15N NMR spectroscopy and theoretical calculations. Laxer, A.; Major, D. T.; Gottlieb, H.; Fischer, B. J. Org. Chem. 2001, 66, 5463-5481.

  • Novel adenosine 5’-triphosphate analogue with potential for P2Y1-receptor isolation pharmacologically characterized in HEK 293 cells highly expressing the rat brain P2Y1-reecptor. Zundorf, G.; Schafer, R.; Vohringer, C.; Halbfinger, E.; Fischer, B.; Reiser, G. Biochem. Pharmacol. 2001, 61, 1259-1269.

  • Inhibitors of NTPDase: Key players in the metabolism of extracellular purines. Gendron, F.P.; Halbfinger, E;. Fischer, B.; Beaudoin, A.R Advan. Experiment. Biol. 2000, 486, 119-123.

  • P2-Receptor agonists – From molecular recognition studies to potential clinical applications. Fischer, B. Drug Dev. Res. 2000, 50, 338-354.

  • Novel nucleoside triphosphate diphosphohydrolase inhibitors: Synthesis, biochemical and pharmacological characterization. Gendron, F.-P.; Halbfinger, E.; Fischer, B.; Duval, M.; D’Orleans-Juste, P.; Beaudoin, A. R. J. Med. Chem. 2000, 43, 2239-2247.

  • Synthesis, mechanism and properties of 8-(aryl)-3-b-D-ribofuranosylimidazo [2,1-i] purine 5’-phosphate derivatives. Fischer, B.; Kabha, E.; Gendron, F.-P.; Beaudoin, A. R. Nucleosides and Nucleotides 2000, 19, 1033-1054.

  • A facile synthesis of (15N2) malononitrile. Laxer, A.; Fischer, B. J. Label. Comp. Radiopharm. 2000, 43, 47-53.

  • Molecular recognition of modified adenine nucleotides by the P2Y1-receptor. II. A computational approach. Major, D. T.; Halbfinger, E.; Fischer, B. J. Med. Chem. 1999, 42, 5338-5347.

  • Molecular recognition of modified adenine nucleotides by the P2Y1-receptor. I. A synthetic, biochemical and NMR approach. Halbfinger, E.; Major, D. T.; Ritzmann, M.; Ubl, J.; Reiser, G.; Boyer, J. L.; Harden, T. K.; Fischer, B.; J. Med. Chem. 1999, 42, 5325-5337.

  • 2-Thioether-5’-O-(1-thiotriphosphate) adenosine derivatives as new insulin secretagogues acting through P2Y-receptors. Fischer, B.; Chulkin, A.; Boyer, J. L.; Harden, T. K.; Gendron, F.-P.; Beaudoin, A. R.; Chapal, J.; Hillaire-Buys, D.; Petit, P. J. Med. Chem. 1999, 42, 3636-3646.

  • Characterization of mini-nucleotides as P2X-receptor agonists in rat cardiocyte culture. An Integrated Synthetic, Biochemical and Theoretical Study. Fischer, B.; Yefidoff, R.; Major, D. T.; Rutman-Halili, I.; Shneyvays, V.; Zinman, T.; Jacobson, K. A.; Shainberg, A. J. Med. Chem. 1999, 42, 2685-2696.

  • Therapeutic aApplications of ATP-(P2)-receptors agonists and antagonists. Fischer, B.; Sheihet, L. Exp. Opin. Therp. Patents 1999, 9, 385-399.

  • Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-tert-Boc-protective group. Bechor, Y.; Falb, E.; Fischer, B.; Wexler, B.A.; Nudelman, A. Syn. Comm. 1998, 28, 471-474.

  • Diethyl chlorophosphite – A mild reagent for efficient reduction of nitro compounds to amines. Fischer, B.; Sheihet, L. J. Org. Chem. 1998, 63, 393-395.

  • Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5’-monophosphate. Boyer, J. L.; Siddiqi, S.; Fischer, B.; Romero-Avila, T.; Jacobson, K. A.; Harden, T. K. Br. J. Pharmacol. 1996, 116, 1959-1964.

  • Molecular probes for muscarinic Receptors: Functionalized congeners of selective muscarinic antagonists. Jacobson, K. A.; Fischer, B.; van Rhee, A. M. Life Sci. 1995, 56, 823-830.

  • A ‘cleavable Trifunctional’ approach to receptor affinity labeling: regeneration of binding to A1-adenosine receptors. Jacobson, K. A.; Fischer, B.; X.-D. Ji. Bioconj. Chem. 1995, 6, 255-263.

  • Modeling the P2Y purinoceptor using rhodopsin as template. van Rhee, A. M.; Fischer, B.; van Galen, P. J. M.; Jacobson, K. A. Drug Desig. Deliv. 1995, 13, 133-154.

  • 2-Thioether derivatives of adenine nucleotides are exceptionally potent agonists at adenylyl cyclase-linked P2Y-purinoceptors. Boyer, J. L.; O’Tuel J. W.; Fischer, B.; Jacobson, K. A.; Harden, T. K. Br. J. Pharmacol. 1995, 116, 2611-2616.

  • Structure Activity Relationships of N6-Bezyladenosine-5’-uronamides as A3 Adenosine Agonists. Gallo-Rodriguez, C.; X.-D. Ji; Melman, N.; Siegman, B. D.; Sanders, L. H.; Orlina, J.; Fischer, B.; Pu, Q.; Olah, M. E.; van Galen, P. J. M.; Stiles, G. L.; Jacobson, K. A. J. Med. Chem. 1994, 37, 636-646.

  • Comparative Studies on the Affinities of ATP Derivatives to P2X-Purinoceptors in Rat at Urinary Bladder. Bo, X.; Fischer, B.; Maillard, M.; Jacobson, K. A.; Burnstock, G. Br. J. Pharm. 1994, 112, 1151-1159.

  • Structure Activity Relationships for Derivatives of Adenosine-5’-triphosphate Agonists at P2 Purinoceptors. Burnstock, G.; Fischer, B.; Maillard, M.; Boyer, J. L.; Hoyle, C.; Ziganshin, A.; Ralevic, V.; Knight G.; Brizzolara, A.; von Isakovics, A.; Harden, T. K.; Jacobson, K. A. Drug Dev. Res. 1994, 31, 206-219.

  • Structure Activity Relationships for 2-Thioether Derivatives of Adenosine-5’-triphosphate as Agonists at P2 Purinoceptors. Fischer, B.; Boyer, J. L.; Hoyle, C.; Ziganshin, A.; Ralevic, V.; Knight G.; Brizzolara, A.; Zimmet, J.; Burnstock, G.; Harden, T. K.; Jacobson, K. A. J. Med. Chem. 1993, 36, 3937-3946.

  • Structure Activity Relationships of 8-Styrylxanthines as A2 Selective Adenosine Antagonists. Gallo-Rodriguez, C.; Melman, N.; Fischer, B.; Maillard, M.; van Bergen, A.; van Galen, P. J. M.; Katon, Y.; Jacobson, K. A. J. Med. Chem. 1993, 36, 1333-1342.

  • New Chemistry of Oxazoles. Hassner, A.; Fischer, B. Heterocycles 1993, 35, 1441-1465.

  • Unusual Transformations of Azomethine Yilides Including an Unsymmetrical Dimerization. Fischer, B.; Hassner, A.; Wolk, J. L. Acta Chem. Scand. 1993, 47, 191-195.

  • Multipath Reactions between Intramolecularly Formed Oxazolium Salts and Nucleophiles. Hassner, A.; Fischer, B. J. Org. Chem. 1992, 57, 3070-3075.

  • Novel Heterocycles by Bis Heteroannulation of Oxazoles. Hassner, A.; Fischer, B. J. Org. Chem. 1991, 56, 3419-3425.

  • Intramolecular Formation of Oxazolium Salts and their Reaction with N- and C-Nucleophiles. Hassner, A.; Fischer, B. Tet. Lett. 1990, 31, 7213-7214.

  • Nitrile Additions to C, N-Diacylimines. Formation of 4-Amidooxazoles. Hassner, A.; Fischer, B. J. Org. Chem. 1990, 55, 5225-5229.

  • Do Oxazoles Undergo Diels-Alder Reactions with Heterodienophiles? Hassner, A.; Fischer, B. Tetrahedron, 1989, 45, 3535-3546.

  • 4,5 and 2,5-Additions to Oxazoles. Hassner, A.; Fischer, B. Tetrahedron, 1989, 45, 6249-6262.

  • Studies in Sugar Chemistry. 2. A Simple Method for O-Deacetylation of Polyacylated Sugars. Hertzig, J.; Nudelman, A.; Gottlieb H. E.; Fischer, B. J. Org. Chem. 1986, 51, 727-730.

  • A Novel Method for Stereoselective Glucuronidation. Fischer, B.; Nudelman, A.; Ruse, M.; Hertzig, J.; Gottlieb H. E.; Keinan, E. J. Org. Chem. 49, 4993-498, 1984

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