Prof. Bilha Fischer Lab

Nature is economy, efficiency, and elegance. Indeed, a limited number of small molecules play numerous functions in life. In our research we have selected natural mononucleotides, di-nucleotides, nucleoside-bisphosphates, and oligonucleotides as scaffolds for the synthesis of novel chemical entities, and the development of novel building blocks and synthetic methodologies. Those new molecules target various applications in the field of medicinal chemistry including diagnosis (probes for detection of mRNA cancer markers towards personalized medicine, SNP-typing probes, and detection and quantification by improved RT-PCR probes), and drug development (development of small molecules for the treatment of diabetes Type 2, glaucoma, Alzheimer’s disease, inflammatory bowel diseases, and osteoarthritis, as well as novel siRNAs).